属性
熔点 145-149°C
描述
别名 1H-吡唑-4-硼酸频哪醇酯;吡唑-4-硼酸凤梨醇酯;2-二氧硼烷-2-基)-1H-吡唑;4-(4,4,5,5-四甲基-1,3,2-二氧硼戊环-2-基)吡唑;1H-Pyrazole-4-boronic acid pinacol ester;4,4,5,5-Tetramethyl-2-(1H-pyrazol-2-yl)-1,3,2-dioxaborolane;4,4,5,5-Tetramethyl-2-(pyrazol-4-yl)-1,3,2-dioxaborolane;4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole;Pyrazol-4-ylboronic acid pinacol ester; 4,4,5,5-Tetramethyl-2-(pyrazol-4-yl)-1,3,2-dioxaborolane;4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole
应用 Reagent used for
? Suzuki-Miyaura cross-couplings
? Ruthenium-catalyzed asymmetric hydrogenation
Reagent used in preparation of inhibitors of many highly significant therapeutic enzymes and kinases containing the privileged scaffold pyrazole, including
? VEGF
? Aurora
? Rho (ROCK)
? Janus Kinase 2 (JAK)
? c-MET
? ALK
? S-nitrosoglutathione reductase
? CDC7
? Acetyl-CoA carboxylase
? Prosurvival Bcl-2 protein
? Viral RNA-Dependent RNA polymerase
? Long Chain Fatty Acid Elongase 6
? PI3
? AKT
? Chk1
? Protein Kinase B