别名
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羧化辅酶(氯化);二磷酸硫胺;氯化维生素B1磷酸酯;3-[(4-氨基-2-甲基-5-嘧啶基)甲基]-5-[2-[[羟基-(磷酸基氧代)磷酰]氧]乙基]-4-甲基噻唑氯化物;硫胺素二磷酸盐;Aneurinepyrophosphoric acid; Cocarboxylase; Thiamine pyrophosphate chloride; Vitamin B1 Pyrophosphoric Acid Ester Chloride;
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用途
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decarboxylation mechanisms in biological systems,and to investigate radical reactions of thiamin pyrophosphate in 2-oxoacid oxidoreductases.
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生化机理
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Thiamine pyrophosphate is a coenzyme of transketolase that catalyzes the cleavage of ribulose-5-phosphate; thereby forming D-glyceraldehyde-3-phosph?ate. This reaction requires the addition of an acceptor aldehyde such as ribose-5-phosphate, glyceraldehye or glycolaldehyde. The enzyme is also capable of decarboxylating hydroxypyruvate in the presence of an ‘acceptor aldehyde‘.
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