属性
溶解性 Soluble in DMSO (50 mg/ml), methanol (50 mg/ml), ethanol (~100 mg/ml), DMF (~100 mg/ml), and buffers of ionic strength ≥0.1 M and pH ≥7.4 (~5 mg/ml). Insoluble in water, Soluble in DMSO (50 mg/ml), methanol (50 mg/ml), ethanol (~100 mg/ml), DMF (
存贮条件 保持密封，阴凉干燥处贮存
描述
产品介绍 Flurbiprofen 是一种苯基烷酸衍生物，是非甾体类抗炎药（NSAIDs）
别名 氟比洛芬; 氟吡洛芬; 氟布洛芬; 氟联苯丙酸; 2-(2-氟-4-联苯)丙酸; 氟苯布洛芬; 苯氟布洛芬;2-(2-Fluorobiphenyl-4-yl)propionic Acid
生化机理 Flurbiprofen is a mixture of S(+) and R(-) enantiomers. Flurbiprofen is a cell-permeable, non-steroidal anti-inflammatory (NSAID) agent that acts as a potent inhibitor of Cox-1 (cyclooxygenase-1) and Cox-2 (cyclooxygenase-2) (IC50 = 5 nM for LPS-induced Cox in human peripheral blood cells). The S(+) enantiomer is reported to be more potent as a Cox-2 inhibitor than the R(-) enantiomer. Flurbiprofen suppresses iNOS expression in RAW 264.7 macrophages. It reduces Aβ loads and Congo Red staining in APP+PS1 transgenic mice
应用 A potent inhibitor of Cox-1 and Cox-2