• 奥利司他 >97.0%(HPLC)
  • GA159936 96829-58-2

    Orlistat

产品订购
产品货号规格货期 优惠价 数量
GA159936-100g 100g 准现货 询价
GA159936-25g 25g 准现货 询价
GA159936-5g 5g 准现货 询价
  • 产品信息

属性

存贮条件 贮存温度2-8°C
描述

产品介绍 Lipase Inhibitor, THL (Tetrahydrolipstatin), is a compound that has been shown to rapidly inactivate lipoprotein lipase (LPL). This agent has been found to bind both subunits of LPL, induce tetramerisation, and cause local conformational changes. The exception to lipase inhibition capacities of THL is phospholipase A2, which is not affected by THL. Mechanistic studies suggest that THL inhibits the thioesterase domain of fatty acid synthase (FAS) and as a result halts cell proliferation and causes cell apoptosis. More detailed experiments show that gradually THL affects the retinoblastoma protein pathway and leads to cell-cycle arrest at G1/S boundary. Lipase Inhibitor, THL is an inhibitor of pancreatic and gastric lipase, as well as carboxyl ester lipase (CEL) and diacylglycerol lipase-α (DAGLα). Lipase Inhibitor, THL also activates caspase-3.
别名 ;N-Formyl-L-leucine (1S)-1-[[(2S,3S)-3-Hexyl-4-oxo-2-oxetanyl]methyl]dodecyl Ester; HY-B0218; Tetrahydrolipstatin; Ro-18-0647
生化机理 Orlistat, used in obesity research, is a pancreatic lipase inhibitor that acts locally in the gastrointestinal tract to inhibit lipase.
应用 Orlistat是一种通用的脂肪酶抑制剂,作用于人体十二指肠液的PL,IC50为122 ng/ml。

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