• 地塞米松 ,98%
  • G63474 50-02-2

    Dexamethasone

产品订购
产品货号重量货期 优惠价 数量
G63474-1g 1g 准现货 询价
G63474-5g 5g 准现货 询价
G63474-25g 25g 准现货 询价
  • 产品信息

属性

溶解性 Soluble in ethanol (25 mg/ml), and DMSO (25 mg/ml). Insoluble in water.
敏感性 对光线和空气敏感
存贮条件
熔点 262-264°C
密度
荧光
IC50
pK Values

描述

别名 21α-乙酰氧基-9α-氟-11β;17α-二羟基-16α-甲基孕甾-1,4-二烯-3,20-二酮;9α-氟-16α-甲基氢化泼尼松;9-氟-11,17,21-三羟基-16-甲基(11b,16a)-孕甾-1,4-二烯-3,20-二酮;德沙美松;氟美松;(11β,16α)-9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione;9α-Fluoro-16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione; 9α-Fluoro-16α-methylprednisolone; Prednisolone F
用途 An antiinflammatory glucocorticoid
生化机理 Dexamethasone is an antiinflammatory glucocorticoid that induces the production of phospholipase A2 inhibitory protein (lipocortin). It also inhibits induction of nitric oxide synthase (IC50=5 nM). Dexamethasone has been shown to cause reduction in cyclin A and Cdk2 activity, inhibition of G1/S transition in osteoblasts and inhibition of phosphorylation of Rb protein. Dexamethasone has been observed to induce apoptosis in human thymocytes and eosinophils, but inhibits apoptosis in neutrophils. Dexamethasone is an activator of IDO.

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