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  2. 化学标准品
  • Gemcitabine ,≥99%

  • G63589 95058-81-4

    Gemcitabine

产品订购
产品货号规格货期 优惠价 数量
G63589-20mg 20mg 准现货 询价
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  • 产品信息

属性

溶解性
  • DMSO 15 mg/mL
  • Water <1 mg/mL
  • Ethanol <1 mg/mL
    • 存贮条件 储存温度-20°C
    密度 否
    荧光 否
    IC50 否
    pK Values 否

    描述

    别名 吉西他滨; 4-氨基-1-[3,3-二氟-4-羟基-5-(羟甲基)氧杂环戊-2-基]嘧啶-2-酮;4-Amino-1-[3,3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one
    产品介绍 2‘-Deoxy-2‘,2‘-difluorocytidine is an irreversible inactivator of R1 and R2 (ribonucleoside diphosphate reductase, RDPR) from Escherichia coli.
    用途 An irreversible inactivator of bacterial ribonucleoside diphosphate reductase.
    生化机理

    Gemcitabine is a widely used antitumor agents in both clinics and research labs. It is an antineoplastic agent and antimetabolite. Gemcitabine is converted intracellularly to the active metabolites difluorodeoxycytidine di- and triphosphate (dFdCDP, dFdCTP). dFdCDP inhibits ribonucleotide reductase, thereby decreasing the deoxynucleotide pool available for DNA synthesis; dFdCTP is incorporated into DNA, resulting in DNA strand termination and apoptosis. Gemcitabine inhibits proliferation BxPC-3 pancreatic cancer cell line with IC50 of 0.06 μM.

    备注 Gemcitabine(Gemzar) belongs to the group of medicines called antimetabolites.

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