属性
溶解性 Soluble in DMSO (>25 mg/ml), ethanol (>25 mg/ml), chloroform, dichloromethane, ethyl acetate, hexane, ether, and acetone.
存贮条件 储存温度-20°C,充氩保存
描述
产品介绍 Geranylgeraniol, a precursor to geranylgeranylpyrophosphate, is an intermediate in the mevalonate pathway. This compound has been shown to prevent bone re-absorption, inhibition of osteoclast formation, and kinase activation in vitro When working with statins, geranylgeraniol can reduce the toxicity without inhibiting the cholesterol-producing effects. Geranylgeraniol has been documented to counteract the effects of fluvastatin by inhibiting activation of caspase-1 and production of IL-1. It has been found to induce apoptosis in HL-60 cells.
别名 all trans-3,7,11-15-四甲基-2,6,10,14-十六烷四烯-1-醇;(2E,6E,10E)-3,7,11,15-四甲基-2,6,10,14-十六碳四烯-1-醇;all trans-3,7,11-15-Tetramethyl-2,6,10,14-hexadecatetraen-1-ol; Tetraprenol; Trans,Trans,Trans-Geranylgeraniol
生化机理 As the pyrophosphate, the metabolic precursor of all diterpenes. Screening in vitro shows this to be a potent and selective agent against Mycobacterium tuberculosis.
应用 香叶基香叶醇本身具有广泛的生理活性，是多种具有生化意义的产物的生化合成前体，如萜类、胡萝卜素、甾体、胆固醇和紫杉醇等。