紫杉醇 ,分析标准品,HPLC≥98%-33069-62-4

产品货号	规格	货期	优惠价	数量
B23008-100mg	100mg	准现货	询价
B23008-20mg	20mg	准现货	询价

产品货号

规格

货期

优惠价

数量

B23008-100mg

100mg

准现货

询价

B23008-20mg

20mg

准现货

询价

溶解性	Soluble in ethanol (~1.5 mg/ml), DMSO (5 mg/ml), acetonitrile, methanol (50 mg/ml), chloroform, 1:10 DMSO:PBS(pH 7.2) (~0.1 mg/ml), and DMF (~5 mg/ml). Insoluble in water.
存贮条件	储存温度2-8°C
熔点	213-216°C
密度	1.3900
旋光率	-49 ° (C=1, MeOH)
荧光	否
IC50	否
pK Values	否

溶解性

Soluble in ethanol (~1.5 mg/ml), DMSO (5 mg/ml), acetonitrile, methanol (50 mg/ml), chloroform, 1:10 DMSO:PBS(pH 7.2) (~0.1 mg/ml), and DMF (~5 mg/ml). Insoluble in water.

存贮条件

储存温度2-8°C

熔点

213-216°C

密度

1.3900

旋光率

-49 ° (C=1, MeOH)

荧光

否

IC50

否

pK Values

否

别名	Taxol
产品介绍	Paclitaxel是一种微管聚合物稳定剂，作用于人内皮细胞，IC50为0.1 pM
用途	有效的抗肿瘤的药物;结合β-微管蛋白的N -端区域，促进了高度稳定的微管形成体，抵制解聚，防止正常细胞分裂和捕获在细胞周期的G2 / M期。
生化机理	Taxol, an antineoplastic and antimicrotubule agent, posses mechanisms of cytotoxic action and has a broad antineoplastic spectrum compared to the vinca alkaloids. Studies have shown that Taxol is an inhibitor of neurite outgrowth and initiation by destroying normal control of microtuble assemly in growing neurites and removing tubulin from the cytoplasm. At lower concentrations Taxol displays the capacity to slightly enhance the mechanisms of microtubule assembly in neurons, and in turn changes the morphogenetic properties of growing neurites. The mechanism for microtuble formation occurs by binding of Taxol to the N-terminal region of β-tubulin. These new microtubules are highly stable and resist depolymerization therefore preventing normal cell division and arresting cell cycle at the G2/M phase. It has been reported that Taxol also causes apoptotic cell death, internucleosomal DNA fragmentation, and inhibition of protein isoprenylation. Taxol is a potential activator of PKA and Raf

别名

Taxol

产品介绍

Paclitaxel是一种微管聚合物稳定剂，作用于人内皮细胞，IC50为0.1 pM

用途

有效的抗肿瘤的药物;结合β-微管蛋白的N -端区域，促进了高度稳定的微管形成体，抵制解聚，防止正常细胞分裂和捕获在细胞周期的G2 / M期。

生化机理

Taxol, an antineoplastic and antimicrotubule agent, posses mechanisms of cytotoxic action and has a broad antineoplastic spectrum compared to the vinca alkaloids. Studies have shown that Taxol is an inhibitor of neurite outgrowth and initiation by destroying normal control of microtuble assemly in growing neurites and removing tubulin from the cytoplasm. At lower concentrations Taxol displays the capacity to slightly enhance the mechanisms of microtubule assembly in neurons, and in turn changes the morphogenetic properties of growing neurites. The mechanism for microtuble formation occurs by binding of Taxol to the N-terminal region of β-tubulin. These new microtubules are highly stable and resist depolymerization therefore preventing normal cell division and arresting cell cycle at the G2/M phase. It has been reported that Taxol also causes apoptotic cell death, internucleosomal DNA fragmentation, and inhibition of protein isoprenylation. Taxol is a potential activator of PKA and Raf

标识符号	GHS05, GHS08, GHS07
信号词	Danger
危害声明	H318,H361f,H341,H332,H312,H302,H335,H315,H334,H317
警示性声明	P280,P305+P351+P338,P260,P261,P342+P311
个人防护设备	Eyeshields,Faceshields,full-face particle respirator type N100 (US),Gloves,respirator cartridge type N100 (US),type P1 (EN143) respirator filter,type P3 (EN 143) respirator cartridges
危害码（欧洲）	Xn
风险声明 (欧洲)	R40;R41;
安全声明（欧洲）	S26;S36/37/39/;S45;
RIDADR	否
WGK德国	3
闪点（华氏）	N/A
Merck Index	6982
RTECS	DA8340700