敏感性 | 对空气敏感 |
---|---|
存贮条件 | 储存温度2-8℃,充氩保存 |
熔点 | 192-195°C |
密度 | 1.4410 |
旋光率 | -17 ° (C=2, H2O) |
荧光 | 否 |
IC50 | 否 |
pK Values | 否 |
别名 | GSH;三缩氨基酸;硫糠质;L-还原型谷胱甘肽;还原型谷胱甘肽;还原谷胱甘肽;5-L-谷氨酰-L-半胱氨酰甘氨酸;GSH;L-Glutathione reduced;γ-L-Glutamyl-L-cysteinyl-glycine |
---|---|
产品介绍 | 氨基酸序列:γ-Glu-Cys-Gly |
用途 | 做为体内一种重要的抗氧化剂,它能够清除掉人体内的自由基。解毒药,主要用于重金属、丙烯腈、氟化物、一氧化碳及有机溶剂等中毒。可用5-10 mM从谷胱甘肽琼脂糖中洗脱谷胱甘肽-S-转移酶(GST)。 |
生化机理 | Endogenous antioxidant that plays a major role in reducing reactive oxygen species formed during cellular metabolism and the respiratory burst. Glutathione-S-transferase catalyzes the formation of glutathione thioethers with xenobiotics, leukotrienes, and other molecules that have an electrophilic center. Glutathione also forms disulfide bonds with cysteine residues in proteins. Via these mechanisms, it can have the paradoxical effect of reducing the efficacy of anti-cancer agents. |
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