溶解性 | Soluble in water (160 mg/ml) at 25 °C, sesame and corn oils (<1 mg/ml) at 25 °C, methanol (>100 mg/ml), ethanol (>100 mg/ml), isopropanol (>100 mg/ml), chloroform (>100 mg/ml), and dichloromethane (>100 mg/ml). |
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敏感性 | 对空气敏感 |
存贮条件 | 储存温度-20°C |
熔点 | 106°C |
密度 | 否 |
旋光率 | -127.5° |
荧光 | 否 |
IC50 | 否 |
pK Values | 否 |
别名 | N-[(S)-3-巯基-2-甲基丙酰基]-L-脯氨酸;(S)-1-(3-巯基-2-甲基-1-氧代丙基)-L-脯氨酸;巯甲丙脯酸;1-((2S)-2-甲基-3-巯基-1-氧代丙基)-L-脯氨酸;Capoten; Cesplon; L-Captopril;N-[(S)-3-Mercapto-2-methylpropionyl]-L-proline;(S)-(-)-1-(3-Mercapto-2-methyl-1-oxopropyl)-L-proline ;(S)-(-)-1-(3-Mercapto-2-methylpropionyl)-L-proline |
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产品介绍 | Captopril is a reversible and competitive inhibitor of leukotriene A4 hydrolase (LTA4H; IC50 = 11μM). Captopril has been shown to be an inhibitor of angiotensin converting enzyme-1 (ACE1), but not ACE2 (IC50 = 22 nM). Captopril demonstrates noncompetitive inhibition of tyrosinase monophenolase activity and competitive inhibition of diphenolase activity. Captopril has also been shown to inhibit the formation of angiotensin II, a bioactive peptide that stimulates angiogenesis and increases microvessel density. |
用途 | Captopril是一种血管紧张素转换酶(ACE)抑制剂,IC50为6 nM。 |
生化机理 | 血管紧张素转换酶抑制剂。抑制血管紧张素 II 的形成,血管紧张素 II 是生物活性多肽,可促进血管生成并增加微血管密度。 |
备注 | Captopril is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 6 nM. |
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