玉米烯酮分析标准品,HPLC≥98%- 17924-92-4

产品货号	规格	货期	优惠价	数量
G63759-5mg	5mg	准现货	询价

产品货号

规格

货期

优惠价

数量

G63759-5mg

5mg

准现货

询价

溶解性	Soluble in methanol (5 mg/ml), chloroform, ethanol (100 mM), and DMSO (100 mM). Insoluble in water
敏感性	对光线敏感
存贮条件	储存温度:-20℃
密度	1.1680
荧光	否
IC50	否
pK Values	否

溶解性

Soluble in methanol (5 mg/ml), chloroform, ethanol (100 mM), and DMSO (100 mM). Insoluble in water

敏感性

对光线敏感

存贮条件

储存温度:-20℃

密度

1.1680

荧光

否

IC50

否

pK Values

否

别名	玉米赤霉烯酮;F-2 toxin;[S-(E)]-3,4,5,6,9,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradecin-1,7(8H)-dione
产品介绍	Zearalenone, a phytoestrogenic mycotoxin usually produced by Fusarium species, is shown to be a cytotoxic compound, but alos binds to the estrogen receptor (ER) (IC50 values are 166 and 240 nM for ERβ and ERα respectively) and was found to stimulate the transcriptional activity of both subtypes at concentrations between 1 - 10 nM. This agent has demonstrated the ability to induce apoptosis via activation of mitochondrial release of Cytochrome c, production of reactive oxygen species (ROS), activation of caspase-3 and caspase-8, and induction of endoplasmic reticulum stress. Additional studies suggest that Zearalenone also up-regulates Bax expression and down-regulates Bcl-xL expression in cells, which also contribute to a halt in cell proliferation. The cell growth arrests caused by this mycotoxin seem to take place during the G1 phase of the cell cycle.
用途	A phytoestrogenic mycotoxin and ER activator
生化机理	Zearalenone, a fungal mycotoxin produced by Fusarium, binds the estrogen receptor (ER) and is uterotropic in the newborn rat. It is a common contaminant in cereal grain used for animal and human food, and exerts an estrogenic activity that modulates/disrupts endocrine function in animals and possibly humans

别名

玉米赤霉烯酮;F-2 toxin;[S-(E)]-3,4,5,6,9,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradecin-1,7(8H)-dione

产品介绍

Zearalenone, a phytoestrogenic mycotoxin usually produced by Fusarium species, is shown to be a cytotoxic compound, but alos binds to the estrogen receptor (ER) (IC50 values are 166 and 240 nM for ERβ and ERα respectively) and was found to stimulate the transcriptional activity of both subtypes at concentrations between 1 - 10 nM. This agent has demonstrated the ability to induce apoptosis via activation of mitochondrial release of Cytochrome c, production of reactive oxygen species (ROS), activation of caspase-3 and caspase-8, and induction of endoplasmic reticulum stress. Additional studies suggest that Zearalenone also up-regulates Bax expression and down-regulates Bcl-xL expression in cells, which also contribute to a halt in cell proliferation. The cell growth arrests caused by this mycotoxin seem to take place during the G1 phase of the cell cycle.

用途

A phytoestrogenic mycotoxin and ER activator

生化机理

Zearalenone, a fungal mycotoxin produced by Fusarium, binds the estrogen receptor (ER) and is uterotropic in the newborn rat. It is a common contaminant in cereal grain used for animal and human food, and exerts an estrogenic activity that modulates/disrupts endocrine function in animals and possibly humans

标识符号	GHS02, GHS07
信号词	Danger
危害声明	H225,H302,H312,H319,H332
警示性声明	P210,P280,P305+P351+P338
个人防护设备	Eyeshields,Faceshields,full-face respirator (US),Gloves,multi-purpose combination respirator cartridge (US),type ABEK (EN14387) respirator filter
危害码（欧洲）	F,Xn
风险声明 (欧洲)	11,20/21/22,36
安全声明（欧洲）	16,26,36
RIDADR	否
WGK德国	3
闪点（华氏）	N/A
闪点（摄氏）	6 °C
UN代码	3261
是否危化品	否

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