盐酸阿霉素 ,USP级，98%（HPLC）,ELISA试剂盒-酶联免疫试剂盒-优质生化试剂供应商|上海晶抗生物

产品货号	规格	货期	优惠价
G62533-25mg	25mg	准现货	询价
G62533-100mg	100mg	准现货	询价
G62533-500mg	500mg	准现货	询价

产品货号

规格

货期

优惠价

数量

G62533-25mg

25mg

准现货

询价

G62533-100mg

100mg

准现货

询价

G62533-500mg

500mg

准现货

询价

溶解性	溶于水、DMSO、四氢呋喃和醇，不溶于丙酮、苯、氯仿、乙醚。水中溶解度: 10 mg/mL, 水溶液为橙红色透明溶液。,
敏感性	对光和湿度敏感
存贮条件	储存温度：2-8°C
熔点	216°C
密度	否
荧光	否
IC50	否
pK Values	否

溶解性

溶于水、DMSO、四氢呋喃和醇，不溶于丙酮、苯、氯仿、乙醚。水中溶解度: 10 mg/mL, 水溶液为橙红色透明溶液。,

敏感性

对光和湿度敏感

存贮条件

储存温度：2-8°C

熔点

216°C

密度

否

荧光

否

IC50

否

pK Values

否

别名	盐酸多柔比星，羟基柔红霉素盐酸盐，DOX 多柔比星? 盐酸盐;Adriamycin hydrochloride;DOX;Hydroxydaunorubicin hydrochloride
产品介绍	Doxorubicin (Adriamycin)是一种抗生素类试剂，抑制DNA拓扑异构酶II，且诱导DNA损伤和凋亡。
用途	抗肿瘤抗生素，在心脏线粒体DNA方面有阿霉素的效果。反相转录酶和RNA聚合酶的抑制剂，免疫抑制剂；可插入DNA链中。临床上是癌症化疗剂、主要用于急、慢性白血病、恶性淋巴瘤。
生化机理	Doxorubicin hydrochloride is a DNA intercalator and powerful cytotoxic agent. Once it associates with the DNA groove, a covalent linkage forms between a DNA base and the pendant sugar of the small molecule. The intercalation into DNA blocks the replication of DNA by blocking Topo II (Topoisomerase II) This general mechanism gives it efficacy in a wide range of different cell types. Additionally, the expression of the oncogenes c-Myc and c-Jun is also down regulated by the chemical and a significant correlation was reported between the level of expression of these genes and the degree of cell growth inhibition conferred by Doxorubicin. Doxorubicin hydrochloride is an inhibitor of AMPK, TERT and POLR.
合法信息	Adriamycin is a registered trademark of RDF Pharmacia & Upjohn S.P.A.

别名

盐酸多柔比星，羟基柔红霉素盐酸盐，DOX 多柔比星? 盐酸盐;Adriamycin hydrochloride;DOX;Hydroxydaunorubicin hydrochloride

产品介绍

Doxorubicin (Adriamycin)是一种抗生素类试剂，抑制DNA拓扑异构酶II，且诱导DNA损伤和凋亡。

用途

抗肿瘤抗生素，在心脏线粒体DNA方面有阿霉素的效果。反相转录酶和RNA聚合酶的抑制剂，免疫抑制剂；可插入DNA链中。临床上是癌症化疗剂、主要用于急、慢性白血病、恶性淋巴瘤。

生化机理

Doxorubicin hydrochloride is a DNA intercalator and powerful cytotoxic agent. Once it associates with the DNA groove, a covalent linkage forms between a DNA base and the pendant sugar of the small molecule. The intercalation into DNA blocks the replication of DNA by blocking Topo II (Topoisomerase II) This general mechanism gives it efficacy in a wide range of different cell types. Additionally, the expression of the oncogenes c-Myc and c-Jun is also down regulated by the chemical and a significant correlation was reported between the level of expression of these genes and the degree of cell growth inhibition conferred by Doxorubicin. Doxorubicin hydrochloride is an inhibitor of AMPK, TERT and POLR.

合法信息

Adriamycin is a registered trademark of RDF Pharmacia & Upjohn S.P.A.

标识符号	GHS07, GHS08
信号词	Danger
危害声明	H302,H350
警示性声明	P201,P308+P313
个人防护设备	Eyeshields,full-face particle respirator type N100 (US),Gloves,respirator cartridge type N100 (US),type P1 (EN143) respirator filter,type P3 (EN 143) respirator cartridges
危害码（欧洲）	T
风险声明 (欧洲)	R22;R45;
安全声明（欧洲）	S45;S53;
RIDADR	否
WGK德国	3
闪点（华氏）	N/A
RTECS	QI9295900
是否危化品	否

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