属性

敏感性 对湿度敏感
存贮条件 储存温度-20°C
描述

别名 HF-吡啶 ;氟化氢吡啶;Olanh试剂;PPHF;HF-Pyridine; Olah′s reagent; PPHF; Poly(pyridine fluoride); Pyridine hydrofluoride; Pyridinium poly(hydrogen fluoride); Pyridinium polybifluoride
备注 储存期间可能含有或形成少量氟化钙。该物质的存在不会?对性能指标产生影响。
应用 Convenient form of anhydrous HF, stable up to 50°C. Has been used for the preparation of β-fluoroamines from amino alcohols and for the fluorination of acetylenes.
Used together with hypervalent iodine(III) reagents for ipso-fluorination of para-substituted phenols providing cyclohexadienones. Employed for geminal fluorination of 2,2-diaryl-1,3-dithiolane?s.

Reactant for preparation of:
Epimers of shikimic acid with the features of fucosylated glycans via zinc-mediated reductive ring opening followed by a Barbier reaction
Vaccinia H1-related (VHR) phosphatase inhibitor with a nonacidic phosphate-mimicking core structure
Candidates for nucleic acid drugs
ω-substituted gem-difluoroalkanes by oxidative desulfurization-difluorin?ation

Reagent for:
Halofluorination reactions