描述
别名 4-(3-氯-2-吡啶基)-N-[4-叔丁基苯基]-1-哌嗪甲酰胺;4-(3-Chloro-2-pyridinyl)-N-[4-(1,1-dimethylethyl)phenyl]-1-piperazinecarboxamide
生化机理 BTBC is an effective and potent transient receptor potential VR1 (vanilloid-1, TRPV1) channel antagonist. VR1 (TRPV1) is a Capsaicin receptor that behaves as a non-selective cation channel that is mainly found in the sensory neurons, and specifically detects painful stimuli, low pH and heat. Studies show that BTBC and Capsazepine both inhibit the activation of rat VR1 (vanilloid receptor 1), induced with acid or Capsaicin. Other VR1 (TRPV1) antagonists include AMG9810 and SB705498. BCTC is an inhibitor of ANKTM1 and TRPM8.
应用 An effective and potent TRPV1 channel antagonist