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别名
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三羟黄酮; 黄芩苷元; 黄芩黄素; 黄芩甙元; 5,6,7-三羟基黄酮;5,6,7-Trihydroxyflavone
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产品介绍
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Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis, that inhibits cellular Ca2+ uptake, calcium mobilization, and adjuvant-induced arthritis. Baicalein has been shown to inhibit platelet 5-LO (5-lipoxygenase) (IC50=9.5 mM) and 12-LO (12-lipoxygenases) (IC50=0.12 mM) and reverse transcriptase. Baicalein reduces leukotriene biosynthesis and inhibits the release of lysosomal enzymes. Baicalein is a potent anti-inflammatory and anti-tumor agent, and it blocks PREP (prolyl oligopeptidase). Baicalein induces the S-phase arrest and apoptosis in proliferation of human lung squamous carcinoma CH27 cells. The declining expression of cdk1, cdk2, cyclin D2 and cyclin A by Baicalein resulted in the G1 and G2 cell cycle arrest in C6 rat glioma cells. Baicalein has anti-thrombotic, antiproliferative and anti-mitogenic effects. Baicalein inhibits protein tyrosine kinase in leukemia (CEM) cells and PMA-stimulated PKC (protein kinase C). Baicalein is an inhibitor of 15-LO and CYP2C9.
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用途
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An inhibitor of Ca2+ uptake, 5-LO, and 12-LO
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生化机理
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中药类黄酮的组成成分，黄芩的主要黄酮，抑制花生四烯酸代谢中的12-脂肪氧化酶路径（12-lipoxygenase ，12-LOX），此路径能抑制癌细胞的增殖，诱导凋亡途径。
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3,4-二甲氧基苯甲酸 9...
S-碘化丁酰硫代胆碱 98%
S-联萘酚 99%
α,α,α-三氟苯乙酮 99...
苯基三乙氧基硅烷 ,98%
苯甲醇 ,AR,≥99%
正辛酸 CP,98%
辛酸钠 99%
氯化镁，AR，98%
1-苯基-1,3-丁二酮 ,...
2-氨基-3-(三氟甲基)吡...
α-松油醇 ，GC≥96%
苯丁酸，AR,97%
4-硝基吲唑，97%
4-氯咪唑，97%
聚(4-苯乙烯磺酸钠)，av...
2-溴苯甲胺，98%
N-羟基正辛酰胺，98%
2,2 -双噻吩，98%
4,4 -二溴二苯甲酮，97...
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