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别名
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普鲁卡因盐酸盐; 4-氨基苯甲酸-2-（二乙氨基）乙酯盐酸; 2-(二乙氨基)乙基4-氨基苯甲酸酯盐酸盐; 对氨基苯甲酸-2-二乙胺基乙酯盐酸盐; 2-二乙基氨基乙基4-氨基苯甲酸酯盐酸盐; 奴佛卡因盐酸盐;4-Aminobenzoic acid 2-diethylaminoethyl ester; p-Aminobenzoic acid diethylaminoethyl ester hydrochloride; Novocaine hydrochloride2-Diethylaminoethyl 4-Aminobenzoate Hydrochloride
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产品介绍
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Procaine HCl是一种钠离子通道的，NMDA受体以及乙酰胆碱受体抑制剂， IC50分别为60 μM， 0.296 mM何45.5 μM，也是一种，5-HT3抑制剂，KD为1.7 μM。
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用途
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A sodium channel blocker and DNA methylation inhibitor
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生化机理
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Procaine hydrochloride is a salt of the compound Procaine. Procaine is a noted sodium channel blocker with a variety of inhibitory effects. In skeletal muscle, Procaine has been reported to inhibit calcium-induced calcium release (CICR). Procaine is also noted to act as a DNA methylation inhibitor and to cause demethylation and reactivation of methylation-silenced genes such as RARβ and GSTP1. WIF-1 is noted to be reactivated in a cancer cell line and to downregulate the Wnt canonical pathway. In studies utilizing a neuroblastoma cell line (SHEP), Procaine is reported to induce neuronal apoptosis in a manner correlated with lipid solubility of the compound. In an adult mouse muscle cell line (HEK293), the presence of procaine is reported to potently inhibit nicotinic acetylcholine receptors. Procaine is available alone and in its salt form as Procaine HCl .
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021-54720761
021-54720761
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3,4-二甲氧基苯甲酸 9...
S-碘化丁酰硫代胆碱 98%
S-联萘酚 99%
α,α,α-三氟苯乙酮 99...
苯基三乙氧基硅烷 ,98%
苯甲醇 ,AR,≥99%
正辛酸 CP,98%
辛酸钠 99%
氯化镁，AR，98%
1-苯基-1,3-丁二酮 ,...
2-氨基-3-(三氟甲基)吡...
α-松油醇 ，GC≥96%
苯丁酸，AR,97%
4-硝基吲唑，97%
4-氯咪唑，97%
聚(4-苯乙烯磺酸钠)，av...
2-溴苯甲胺，98%
N-羟基正辛酰胺，98%
2,2 -双噻吩，98%
4,4 -二溴二苯甲酮，97...
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