• 梭菌蛋白酶,BR,50u/mg
  • G63379 9028-00-6

    Clostripain from Clostridium histolyticum

产品订购
产品货号重量货期 优惠价 数量
G63379-1mg 1mg 准现货 询价
G63379-5mg 5mg 准现货 询价
  • 产品信息

属性

存贮条件 储存温度2-8℃
密度
荧光
IC50
pK Values

描述

别名 ;Endoproteinase-Arg-C;Clostridiopeptidase B;Proteinase from Clostridium histolyticum
产品介绍 Clostripain (Endoproteinase-Arg-C) is a two chain proteinase associated with collagenase and isolated from Clostridium histolyticum. It is highly specific for the carboxyl peptide bond of arginine. Clostripain has a sulfhydryl requirement; it is activated by dithiothreitol, cysteine, or other sulfhydryl containing reagents. The presence of calcium ions is essential. The enzyme is inhibited by oxidizing agents and sulfhydryl reactants and by Co2+, Cu2+, Cd2+, and heavy metal ions. Citrate, borate, and Tris anions are less inhibitory.
用途 A protease that cleaves proteins on the carboxyl bond of arginine
生化机理 Clostripain from Clostridium histolyticum is composed of two polypeptide chains, with molecular masses of 41.7 kDa and 15.4 kDa. Clostripain has a highly restricted substrate specificity for Arg-Xaa peptide bonds. Therefore, clostripain has been explored as a potential enzyme for protein sequencing purposes. It has also been studied as a catalyst for condensation of pharmaceutically important peptides containing Arg-Pro bonds.

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