普卡酶素 ,≥95%,elisa试剂盒,elisa检测试剂盒,上海晶抗生物工程有限公司

产品货号	重量	货期	优惠价
G63540-1mg	1mg	准现货	询价
G63540-5mg	5mg	准现货	询价
G63540-25mg	25mg	准现货	询价

产品货号

重量

货期

优惠价

数量

G63540-1mg

1mg

准现货

询价

G63540-5mg

5mg

准现货

询价

G63540-25mg

25mg

准现货

询价

溶解性	Soluble in phosphate buffered saline (1 mg/ml), ethanol, ethyl acetate, lower alcohols, and acetone. Insoluble in water.
敏感性	对光敏感
存贮条件	储存温度-20°C
熔点	170-175°C
密度	1.4800
荧光	否
IC50	否
pK Values	否

溶解性

Soluble in phosphate buffered saline (1 mg/ml), ethanol, ethyl acetate, lower alcohols, and acetone. Insoluble in water.

敏感性

对光敏感

存贮条件

储存温度-20°C

熔点

170-175°C

密度

1.4800

荧光

否

IC50

否

pK Values

否

别名	普卡酶素 ;光辉酶素;光神霉素;普芳拉星;金霉酸;Mithramycin A;Mithramycin;Aureolic acid;Mithramycin A
产品介绍	Mithramycin A is an antibiotic DNA/RNA polymerase and DNA binding transcriptional inhibitor observed to facilitate TNF-α and Fas-ligand induced apoptosis. As a DNA binding transcriptional inhibitor, mithramycin A binds to GC rich sequences located in the minor groove of DNA and is noted to be reversible and Mg2+ dependent. Additionally reported to a block transcriptional activation of the SV40 promoter via competitive binding against Sp1 transcription factor to GC rich areas in the early promoter. Mithramycin A is noted to supress TNF-α induced expression of fractalkine (CX3CL1) mRNA in a dose-dependent manner and to act as an effective differentiation agent of HL60 promyelocytic leukemia cells
用途	A polymerase inhibitor that binds to GC rich sequences located in the minor groove of DNA;DNA binding fluorescent dye. Until 2000 it was used to reduce high levels of plasma calcium; Used as an antineoplastic agent
生化机理	Anticancer antibiotic. Inhibits transcription and protein synthesis. Binds to DNA in native chromatin. Substrate of Pgp in MDR phenotypes.

别名

普卡酶素 ;光辉酶素;光神霉素;普芳拉星;金霉酸;Mithramycin A;Mithramycin;Aureolic acid;Mithramycin A

产品介绍

Mithramycin A is an antibiotic DNA/RNA polymerase and DNA binding transcriptional inhibitor observed to facilitate TNF-α and Fas-ligand induced apoptosis. As a DNA binding transcriptional inhibitor, mithramycin A binds to GC rich sequences located in the minor groove of DNA and is noted to be reversible and Mg2+ dependent. Additionally reported to a block transcriptional activation of the SV40 promoter via competitive binding against Sp1 transcription factor to GC rich areas in the early promoter. Mithramycin A is noted to supress TNF-α induced expression of fractalkine (CX3CL1) mRNA in a dose-dependent manner and to act as an effective differentiation agent of HL60 promyelocytic leukemia cells

用途

A polymerase inhibitor that binds to GC rich sequences located in the minor groove of DNA;DNA binding fluorescent dye. Until 2000 it was used to reduce high levels of plasma calcium; Used as an antineoplastic agent

生化机理

Anticancer antibiotic. Inhibits transcription and protein synthesis. Binds to DNA in native chromatin. Substrate of Pgp in MDR phenotypes.

标识符号	GHS07
信号词	Warning
危害声明	H302
个人防护设备	dust mask type N95 (US),Eyeshields,Faceshields,Gloves
危害码（欧洲）	Xn
风险声明 (欧洲)	22
RIDADR	否
WGK德国	3
闪点（华氏）	N/A
RTECS	PZ2800000
UN代码	2811
是否危化品	否

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描述

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