• 壬二酸 99%
  • G64417 123-99-9

    Azelaic acid 99%

产品订购
产品货号规格货期 优惠价 数量
G64417_1 100g 准现货 询价
G64417_2 2.5kg 准现货 询价
G64417_3 25g 准现货 询价
G64417_4 500g 准现货 询价
  • 产品信息

属性

溶解性 Soluble in water (2.4 mg/ml at 20 °C), ethanol (5%), DMSO, methanol (70 mg/ml), and alcohol.
敏感性 对湿度敏感
存贮条件 密封保存。
折光率 1.4303
沸点 286°C
熔点 109-111°C
密度 0.8210
荧光
IC50
pK Values

描述

别名 杜鹃花酸;1,7-壬二酸;庚烷-1,7-二羟酸;王二酸;1,7-庚二甲酸;;Nonanedioic acid;1,7-heptanedicarboxylic acid;
产品介绍 Azelaic acid is a dicarboxylic acid that exhibits anti-inflammatory activity. It is known for it’s anti acne activity in vitro. Azelaic acid directly inhibits kallikrein 5 (KLK5), downregulating expression of KLK5, toll-like receptor 2 (TLR 2), and cathelicidin, and suppresses activity of serine proteases in vitro, in vivo, and in clinical settings. In PUFA-treated fibroblasts, azelaic acid decreases generation of ROS and upregulates expression of antioxidative enzymes, inhibiting cell damage; agonist activity at PPARν is thought to drive these effects. Azelaic acid also inhibits proliferation of melanocytes. This compound displays antiacne and anticancer potential as well, inhibiting the proliferation of cutaneous melanoma due to suppression of mitochondrial oxidoreductive activity and DNA synthesis.
用途 An antiinflammatory compound

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