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  2. 碳水化合物类
  • 2-脱氧-D-葡萄糖 BR ,98%

  • G60277 154-17-6

    2-Deoxy-D-glucose

产品订购
产品货号重量货期 优惠价 数量
G60277-1g 1g 准现货 询价
G60277-25g 25g 准现货 询价
G60277-5g 5g 准现货 询价
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  • 产品信息

属性

存贮条件 储存温度2-8℃
熔点 146-147°C
密度 1.5330
旋光率 46.5 ° (C=1, H2O)
荧光 否
IC50 否
pK Values 否

描述

别名 2-去氧-D-葡萄糖;2-脱氧-D-葡糖;2-Deoxy-D-arabinohexose;2-Deoxyglucose
产品介绍 溶于水和乙醇。
用途 2-脱氧-D-葡萄糖（2-Deoxy-D-Glucose，2-DG）为天然抗代谢物类抗生素，具有能够抑制病毒感染、酵母发酵、致病菌及肿瘤细胞生长等。
生化机理 2-Deoxy-D-Glucose (2-Deoxyglucose) is a glucose analog that inhibits glycolysis via its actions on hexokinase, the rate limiting step of glycolysis. It is phosphorylated by hexokinase to 2-DG-P which can not be further metabolized by phosphoglucose isomerase. This leads to the accumulation of 2-DG-P in the cell and the depletion in cellular ATP. In vitro, 2-Deoxyglucose has been shown to induce autophagy, increase ROS production, and activate AMPK

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